MOTS-c peptide is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. Vi Corpus supplies it as a 10 mg lyophilised vial for Australian laboratories researching metabolism, insulin sensitivity and cellular ageing.
Key research features of MOTS-c peptide
- Mitochondrial origin. It is one of the few known peptides encoded by mitochondrial rather than nuclear DNA.
- AMPK activation. Mouse studies show it activates AMPK and influences the folate cycle in skeletal muscle.
- Metabolic research. Papers have examined diet-induced obesity and insulin resistance models.
- Exercise biology. Levels rise with exercise, which makes it a popular target in physical performance research.
- Third-party tested. Reports are available via our Lab Tests page.
Specifications
| Compound | MOTS-c |
|---|---|
| Amount | 10 mg per vial |
| Form | Lyophilised (freeze-dried) powder |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molar mass | approx. 2174.6 g/mol |
| Reconstitution | Bacteriostatic water (sold separately) |
Research applications
Since its discovery in 2015, MOTS-c has drawn attention in metabolic and longevity science. For instance, researchers reported better glucose handling in mice fed high-fat diets. Other teams have studied age-related decline in physical capacity and the peptide’s movement into the cell nucleus under stress. As a result, it is often studied next to NAD+ in mitochondrial research. Because it circulates in plasma, it also gives researchers a measurable marker for comparing young and aged animal models.
Storing MOTS-c peptide
Keep vials refrigerated at 2–8 °C and away from light. After reconstitution with bacteriostatic water, store the solution cold and use sterile technique for every draw.
Frequently asked questions
Is MOTS-c the same as “mot c peptide”?
Yes. “Mot c peptide” and “MOTS c peptide” are common search spellings of MOTS-c, short for mitochondrial open reading frame of the 12S rRNA-c.
Is MOTS-c approved for human use?
No. It remains an investigational compound, so we sell it for laboratory research use only.
Where can I find related compounds?
Browse our metabolic and longevity peptides.


